Clustered nanobody-drug conjugates for targeted cancer therapy

被引：18
|
作者：
Wu, Tiantian [1 ]
Liu, Manman [1 ]
Huang, Hai [1 ]
Sheng, Yaping [1 ]
Xiao, Haihua [2 ]
Liu, Yangzhong [1 ]
机构：
[1] Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Dept Chem, Hefei 230001, Anhui, Peoples R China
[2] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 65期
基金：
美国国家科学基金会; 国家重点研发计划;
关键词：
EGFR; PEGYLATION; DELIVERY; SITE;
D O I：
10.1039/d0cc03396k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A clustered Nb-drug conjugate (cNDC@PEG) was designed using anti-EGFR Nb to specifically deliver Pt(iv) prodrugs to tumors. cNDC@PEG efficiently targets EGFR positive tumor cells, and the clustered cNDC@PEG is more efficient in inhibiting tumor growthin vivothan the monomeric NDC. This work provides a novel strategy for the construction of a multi-valent NDC using dendrimers.
引用
收藏
页码：9344 / 9347
页数：4
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