Cell Stress Response in Rat Chronic Small Bowel Allograft Rejection

被引：3
|
作者：
Wang, J. [1 ]
Li, Y. [1 ]
Li, J. [1 ]
机构：
[1] Nanjing Univ, Sch Med, Dept Surg, Jinling Hosp, Nanjing 210002, Jiangsu, Peoples R China
来源：
TRANSPLANTATION PROCEEDINGS | 2013年 / 45卷 / 06期
基金：
中国国家自然科学基金;
关键词：
NK CELLS; NKG2D; TRANSPLANTATION; EXPRESSION; LIGANDS; DANGER; RECEPTOR; KIDNEY; MODEL; MICE;
D O I：
10.1016/j.transproceed.2013.02.120
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background. We sought to assess the expression of five cell stress molecules: Heat shock protein (HSP)-60, HSP-70, interferon (IFN)-alpha, rat retinoic acid early induible-1 like transcript (RRLT), and vasoactive intestinal peptide (VIP) during rat chronic small bowel allograft rejection. Methods. A rat model of small bowel allograft rejection was induced on postoperative day 90 using F344 rat as donor and Lewis rat as recipient. Results. We demonstrated increased expression of lamina propria HSP-60 (mean rank grade 8.3 and 3.2, respectively), graft RRLT (relative mRNA amount 5.1 +/- 1.8 and 3.0 +/- 1.3, respectively) and IFN-alpha (relative mRNA amount 108.3 +/- 49.2 and 59.2 +/- 22.0, respectively) in allograft group compared with the isograft group. Conclusion. These data suggest the presence of cell stress during chronic small bowel allograft rejection.
引用
收藏
页码：2539 / 2542
页数：4
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