Dual Roles of Ctf18-RFC: Loading the Clamp and Angling for the Polymerase

被引：8
|
作者：
Pellegrini, Luca [1 ]
机构：
[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
来源：
STRUCTURE | 2018年 / 26卷 / 01期
关键词：
DNA-REPLICATION; COMPLEX; RFC; CHROMATIN; COHESION; EPSILON; DCC1;
D O I：
10.1016/j.str.2017.12.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Clamp loaders such as Ctf18-RFC assist DNA replication by loading the PCNA clamp onto DNA. In this issue of Structure, Grabarczyk et al. (2018) reveal that a hook-like structure formed by the unique Dcc1 and Ctf8 subunits mediates the interaction of Ctf18-RFC with the leading strand DNA polymerase epsilon.
引用
收藏
页码：1 / 2
页数：2
相关论文
共 16 条
  • [11] A conserved Polε binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1
    Garcia-Rodriguez, Luis J.
    De Piccoli, Giacomo
    Marchesi, Vanessa
    Jones, Richard C.
    Edmondson, Ricky D.
    Labib, Karim
    NUCLEIC ACIDS RESEARCH, 2015, 43 (18) : 8830 - 8838
  • [12] Studies with the human cohesin establishment factor, ChlR1 - Association of ChlR1 with Ctf18-RFC and Fen1
    Farina, Andrea
    Shin, Jae-Ho
    Kim, Do-Hyung
    Bermudez, Vladimir P.
    Kelman, Zvi
    Seo, Yeon-Soo
    Hurwitz, Jerard
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (30) : 20925 - 20936
  • [13] DNA Replication and Sister Chromatid Cohesion 1 (DSCC1) of the Replication Factor Complex CTF18-RFC is Critical for Colon Cancer Cell Growth
    Kim, Jong-Tae
    Choi, Hee Jun
    Park, Sang Yoon
    Oh, Byung Moo
    Hwang, Yo Sep
    Baek, Kyoung Eun
    Lee, Young-Ha
    Kim, Hee Cheol
    Lee, Hee Gu
    JOURNAL OF CANCER, 2019, 10 (24): : 6142 - 6153
  • [14] Rmi1 functions in S phase-mediated cohesion establishment via a pathway involving the Ctf18-RFC complex and Mrc1
    Lai, Mong Sing
    Seki, Masayuki
    Tada, Shusuke
    Enomoto, Takemi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 427 (03) : 682 - 686
  • [15] The Ctf18RFC Clamp Loader Is Essential for Telomere Stability in Telomerase-Negative and mre11 Mutant Alleles
    Gao, Honghai
    Moss, Daniel L.
    Parke, Courtney
    Tatum, Danielle
    Lustig, Arthur J.
    PLOS ONE, 2014, 9 (02):
  • [16] Stable Interaction between the Human Proliferating Cell Nuclear Antigen Loader Complex Ctf18-Replication Factor C (RFC) and DNA Polymerase ε Is Mediated by the Cohesion-specific Subunits, Ctf18, Dcc1, and Ctf8
    Murakami, Takeshi
    Takano, Ryuji
    Takeo, Satoshi
    Taniguchi, Rina
    Ogawa, Kaori
    Ohashi, Eiji
    Tsurimoto, Toshiki
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (45) : 34608 - 34615
12