Dual Roles of Ctf18-RFC: Loading the Clamp and Angling for the Polymerase

被引：8
|
作者：
Pellegrini, Luca [1 ]
机构：
[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
来源：
STRUCTURE | 2018年 / 26卷 / 01期
关键词：
DNA-REPLICATION; COMPLEX; RFC; CHROMATIN; COHESION; EPSILON; DCC1;
D O I：
10.1016/j.str.2017.12.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Clamp loaders such as Ctf18-RFC assist DNA replication by loading the PCNA clamp onto DNA. In this issue of Structure, Grabarczyk et al. (2018) reveal that a hook-like structure formed by the unique Dcc1 and Ctf8 subunits mediates the interaction of Ctf18-RFC with the leading strand DNA polymerase epsilon.
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页码：1 / 2
页数：2
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