Palladacycle-Catalyzed Reaction of Bicyclic Alkenes with Terminal Ynones: Regiospecific Synthesis of Polysubstituted Furans

被引：44
|
作者：
Ge, Guang-Cun [1 ]
Mo, Dong-Liang [1 ]
Ding, Chang-Hua [1 ]
Dai, Li-Xin [1 ]
Hou, Xue-Long [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Hong Kong Joint Lab Chem Synth, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 22期
基金：
中国国家自然科学基金;
关键词：
OXABICYCLIC ALKENES; REGIOSELECTIVE SYNTHESIS; TETRASUBSTITUTED FURANS; SUBSTITUTED FURANS; 2+2 CYCLOADDITION; PALLADIUM; ALKYNES; KETONES; DIMERIZATION; DERIVATIVES;
D O I：
10.1021/ol302586m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new synthetic strategy to access polysubstituted furans regiospecifically has been developed using simple bicyclic alkenes and terminal ynones as starting materials with palladacycles as unique active catalysts. A rational mechanism has also been proposed. This reaction features mild reaction conditions, easily available starting materials and palladacycle catalysts, a wide substrate scope, and high regiospecificity.
引用
收藏
页码：5756 / 5759
页数：4
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