Immunosuppressive drug FTY720 sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.

被引：0
|
作者：
Pshezhetskiy, Dmitry [1 ,2 ]
Bohler, Torsten [3 ]
Doumerc, Nicolas [4 ]
Golzio, Muriel [2 ]
Brinkmann, Volker [5 ]
Waxman, Jonathan [1 ]
Malavaud, Bernard [4 ]
Cuvillier, Olivier [2 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, London, England
[2] IPBS, Toulouse, France
[3] Fac Med Toulouse, INSERM, U466, F-31073 Toulouse, France
[4] Hop Rangueil, Toulouse, France
[5] Novartis Pharmaceut, Basel, Switzerland
来源：
FASEB JOURNAL | 2008年 / 22卷
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：1
相关论文
共 50 条
  • [41] FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning
    Vessey, Donald A.
    Li, Luyi
    Imhof, Isabella
    Honbo, Norman
    Karliner, Joel S.
    MEDICAL SCIENCE MONITOR BASIC RESEARCH, 2013, 19 : 126 - 132
  • [42] Sphingosine-1-phosphate Signaling Targeted by FTY720 Suppress Obesity-related Breast Cancer Progression, Metastasis, and Improve Survival
    Takabe, K.
    Nagahashi, M.
    Spiegel, S.
    ANNALS OF SURGICAL ONCOLOGY, 2016, 23 : S24 - S25
  • [43] Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: Functional differences between sphingosine kinase 1a and 1b
    Lima, Keng Gat
    Tonelli, Francesca
    Berdyshev, Evgeny
    Gorshkova, Irina
    Leclercqc, Tamara
    Pitson, Stuart M.
    Bittman, Robert
    Pyne, Susan
    Pyne, Nigel J.
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2012, 44 (09): : 1457 - 1464
  • [44] Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy
    Yang, Heekyoung
    Yoon, Su Jin
    Jin, Juyoun
    Choi, Seung Ho
    Seol, Ho Jun
    Lee, Jung-Il
    Nam, Do-Hyun
    Yoo, Hae Yong
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 406 (01) : 53 - 58
  • [45] (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells (vol 23, pg 1590, 2011)
    Lim, Keng Gat
    Sun, Chaode
    Bittman, Robert
    Pyne, Nigel J.
    Pyne, Susan
    CELLULAR SIGNALLING, 2012, 24 (06) : 1115 - 1115
  • [46] FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration
    Hwang, Su Jin
    Kim, Ji Hyung
    Kim, Hye Young
    Kim, Sanghee
    Chung, Doo Hyun
    LABORATORY INVESTIGATION, 2010, 90 (01) : 9 - 19
  • [47] FTY720, a sphingosine-1-phosphate (S1P) receptor modulator, protects sinusoid endothelial cells from radiation injury in vitro
    Zhang, Shu-Min
    Chen, Yi-Xing
    Sun, Jing
    Guo, Lei
    Zeng, Zhao-Chong
    HEPATOLOGY INTERNATIONAL, 2015, 9 (01) : 149 - 154
  • [48] FTY720, a sphingosine-1-phosphate (S1P) receptor modulator, protects sinusoid endothelial cells from radiation injury in vitro
    Shu-Min Zhang
    Yi-Xing Chen
    Jing Sun
    Lei Guo
    Zhao-Chong Zeng
    Hepatology International, 2015, 9 : 149 - 154
  • [49] Sphingosine kinase inhibition to sensitize hormone-resistant prostate cancer cells to docetaxel
    Pshezhetskiy, Dmitry
    FASEB JOURNAL, 2009, 23
  • [50] Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720
    Tran, Hai B.
    Barnawi, Jameel
    Ween, Miranda
    Hamon, Rhys
    Roscioli, Eugene
    Hodge, Greg
    Reynolds, Paul N.
    Pitson, Stuart M.
    Davies, Lorena T.
    Haberberger, Rainer
    Hodge, Sandra
    JOURNAL OF LEUKOCYTE BIOLOGY, 2016, 100 (01) : 195 - 202
12345