Latent tuberculosis infection in patients with rheumatic diseases

被引：23
|
作者：
Anton, Camila [1 ,2 ,5 ]
Machado, Felipe Dominguez [1 ,2 ,5 ]
Ahumada Ramirez, Jorge Mario [1 ,2 ,5 ]
Bernardi, Rafaela Manzoni [1 ,2 ,5 ]
Palominos, Penelope Esther [3 ,5 ]
Brenol, Claiton Viegas [3 ,5 ]
de Queiroz Mello, Fernanda Carvalho [4 ,5 ]
Silva, Denise Rossato [1 ,2 ,5 ]
机构：
[1] Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Pneumol, Porto Alegre, RS, Brazil
[2] Hosp Clin Porto Alegre, Serv Pneumol, Porto Alegre, RS, Brazil
[3] Hosp Clin Porto Alegre, Serv Reumatol, Porto Alegre, RS, Brazil
[4] Univ Fed Rio de Janeiro, Fac Med, Inst Doencas Torax, Rio De Janeiro, RJ, Brazil
[5] Univ Fed Rio Grande do Sul, Fac Med, Programa Posgrad Ciencias Pneumol, Porto Alegre, RS, Brazil
来源：
JORNAL BRASILEIRO DE PNEUMOLOGIA | 2019年 / 45卷 / 02期
关键词：
Tuberculosis; Latent tuberculosis; Tuberculin skin test; Anti-TNF therapy; Tumor necrosis factor-alpha; Rheumatoid arthritis; NECROSIS-FACTOR-ALPHA; QUANTIFERON-TB-GOLD; KOREAN PATIENTS; HIGH PREVALENCE; INCREASED RISK; SKIN-TEST; ARTHRITIS; THERAPY; RIFAMPIN; CELLS;
D O I：
10.1590/1806-3713/e20190023
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Most people infected by Mycobacterium tuberculosis (Mtb) do not have any signs or disease symptoms, a condition known as latent tuberculosis infection (LTBI). The introduction of biological agents, mainly tumor necrosis factor (TNF) inhibitors, for the treatment of immune-mediated diseases such as Rheumatoid Arthritis (RA) and other rheumatic diseases, increased the risk of reactivation of LTBI, leading to development of active TB. Thus, this review will approach the aspects related to LTBI in patients with rheumatologic diseases, especially those using iTNF drugs. For this purpose it will be considered the definition and prevalence of LTBI, mechanisms associated with diseases and medications in use, criteria for screening, diagnosis and treatment. Considering that reactivation of LTBI accounts for a large proportion of the incidence of active TB, adequate diagnosis and treatment are crucial, especially in high-risk groups such as patients with rheumatologic diseases.
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页数：7
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