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Newcastle Univ, Ctr Stem Cell Biol & Dev Genet, Inst Human Genet, Int Ctr Life, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England Newcastle Univ, Ctr Stem Cell Biol & Dev Genet, Inst Human Genet, Int Ctr Life, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England