Rabies Vaccinations: Are Abbreviated Intradermal Schedules the Future?

被引：26

作者：

Wieten, R. W.

Leenstra, T. ^{[2
]}

van Thiel, P. P. A. M. ^{[2
]}

van Vugt, M.

Stijnis, C. ^{[2
]}

Goorhuis, A.

Grobusch, M. P. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Infect Dis, Ctr Trop & Travel Med,Div Internal Med, NL-1100 DD Amsterdam, Netherlands

[2] Minist Def, The Hague, Netherlands

来源：

CLINICAL INFECTIOUS DISEASES | 2013年 / 56卷 / 03期

关键词：

rabies; vaccination; intradermal; booster; preexposure prophylaxis; DIPLOID CELL STRAIN; ANTIBODY-RESPONSE; VACCINE; IMMUNOGENICITY; IMMUNIZATION; TRAVELERS; RISK;

D O I：

10.1093/cid/cis853

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rabies is a deadly disease, and current preexposure vaccination schedules are lengthy and expensive. We identified nine studies investigating abbreviated schedules. Although initial responses were lower, accelerated adequate immune responses were elicited after booster vaccinations. Lower-dose (and therefore cheaper) vaccination schedules may constitute a valid alternative to current vaccination schedules.

引用

页码：414 / 419

页数：6

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