Quinoline β-lactams by Rh(II)-catalyzed highly steroselective intramolecular carbene insertion into a carbon-hydrogen bond

被引：7

作者：

Muroni, D ^{[1
]}

Saba, A ^{[1
]}

机构：

[1] Univ Sassari, Fac Sci, Dipartimento Chim, Via Vienna 2, I-07100 Sassari, Italy

来源：

ARKIVOC | 2005年

关键词：

metal-carbene; diazoamide; C-H insertion; intramolecular cyclization; beta-lactam; chemoselectivity; stereoselectivity;

D O I：

10.3998/ark.5550190.0006.d01

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis of tricyclic beta-lactams by chemo- and diastereoselective intramolecular CH insertion of metal carbenes generated by dirhodium(II) tetraacetate catalyzed decomposition of alpha-diazoamides 1a-c is reported. In the case of reagent 1b, in the presence of the (+)-menthyl chiral auxiliary, the beta-lactam is obtained with 76% e.e.

引用

页码：1 / 7

页数：7

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