A metal catalyst-free and one-pot synthesis of (3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methanol derivatives in water

被引：4
|
作者：
Singh, Shambhu Nath [1 ,2 ,3 ]
Jayaprakash, Sarva [1 ,2 ]
Reddy, K. Venkateshwara [3 ,4 ]
Nakhi, Ali [5 ]
Pal, Manojit [5 ]
机构：
[1] Custom Pharmaceut Serv, Hyderabad 500049, Andhra Pradesh, India
[2] Dr Reddys Labs Ltd, Hyderabad 500049, Andhra Pradesh, India
[3] JNT Univ, JNTUH Coll Engn, Dept Chem, Hyderabad 500085, Andhra Pradesh, India
[4] JNTU, CMR Engn Coll, Hyderabad 501401, Andhra Pradesh, India
[5] Dr Reddys Inst Life Sci, Hyderabad 500046, Andhra Pradesh, India
来源：
RSC ADVANCES | 2015年 / 5卷 / 103期
关键词：
3,4-DIHYDRO-2H-1,4-BENZOXAZINE DERIVATIVES; ANTITHROMBOTIC COMPOUNDS; DUAL FUNCTION; RECEPTOR; ANTAGONISTS; CHEMISTRY; DISCOVERY;
D O I：
10.1039/c5ra14478g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A robust and metal catalyst-free method has been developed for the general and green synthesis of racemic (3,4-dihydro-2H-benzo[b][1,4] oxazin-2-yl)methanol derivatives. This simple, mild and practical method involves the reaction of 2-aminophenols with (+/-)-epichlorohydrin in the presence of NaOH in water at room temperature. The reaction features high regioselectivity and a good substrate scope to produce both N-substituted and N-unsubstituted products.
引用
收藏
页码：84889 / 84893
页数：5
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