Neuraminidase Inhibitory Polyketides from the Marine-derived Fungus Phoma herbarum

被引：19

作者：

Zhang, Gao Fei ^{[1
,2
]}

Han, Wen Bo ^{[1
]}

Cui, Jiang Tao ^{[1
]}

Ng, Seik Weng ^{[3
]}

Guo, Zhi Kai ^{[1
]}

Tan, Ren Xiang ^{[1
]}

Ge, Hui Ming ^{[1
]}

机构：

[1] Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China

[2] Shenzhen Inst Drug Control, Shenzhen, Peoples R China

[3] Univ Malaya, Dept Chem, Kuala Lumpur 59100, Malaysia

来源：

PLANTA MEDICA | 2012年 / 78卷 / 01期

关键词：

Phoma herbarum; Valsaceae; polyketide; marine fungus; neuraminidase inhibitor; MASSARINA-TUNICATA; METABOLITES; BIOSYNTHESIS;

D O I：

10.1055/s-0031-1280251

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new polyketides, arthropsadiol C (1) and massarilactone H (2), together with six known derivatives (3-8) were isolated from the culture broth of the marine-derived fungus Phoma herbarum. Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 2, 4, 5, and 8 showed moderate neuraminidase inhibitory activity with IC50 values ranging from 4.15 to 9.16 mu M.

引用

页码：76 / 78

页数：3

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