Patient iPSC-derived retinal organoids: Observable retinal diseases in-a-dish

被引：8

作者：

Zhang, Xiao-Hui ^{[1
]}

Jin, Zi-Bing ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Inst Ophthalmol, Beijing Tongren Eye Ctr, Beijing Tongren Hosp,Beijing Ophthalmol & Visual, Beijing, Peoples R China

来源：

HISTOLOGY AND HISTOPATHOLOGY | 2021年 / 36卷 / 07期

基金：

北京市自然科学基金; 国家重点研发计划;

关键词：

Induced pluripotent stem cells; Retinal organoids; Inherited retinal dystrophy; Gene editing; Disease modeling; PLURIPOTENT STEM-CELLS; RETINITIS-PIGMENTOSA; GENE; REVEALS; RETINOBLASTOMA; GENERATION; MUTATIONS; CORRECTS;

D O I：

10.14670/HH-18-307

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Induced pluripotent stem cells (iPSCs), reprogrammed from human somatic cells, hold the capacity to differentiate into most human body cells. iPSCs can be differentiated into retinal organoids, a three-dimensional structured retina containing various retinal cells. Patient-specific retinal organoids provide a powerful disease model to recapitulate the disease to study the pathogenesis of inherited retinal dystrophies, to screen or discover new drugs, and most importantly to supply an unlimited cell source for retinal regeneration.

引用

页码：705 / 710

页数：6

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