Genetics of Pancreatic Cancer and Its Implications on Therapy

被引：13
|
作者：
Tatarian, Talar [1 ]
Winter, Jordan M. [2 ]
机构：
[1] Thomas Jefferson Univ Hosp, Dept Surg, Jefferson Pancreas Biliary & Related Canc Ctr, Sidney Kimmel Med Coll, 1015 Walnut St,Suite 620, Philadelphia, PA 19107 USA
[2] Thomas Jefferson Univ Hosp, Dept Surg, Jefferson Pancreas Biliary & Related Canc Ctr, Sidney Kimmel Med Coll, 1025 Walnut St,Suite 605, Philadelphia, PA 19107 USA
来源：
SURGICAL CLINICS OF NORTH AMERICA | 2016年 / 96卷 / 06期
关键词：
Pancreatic cancer; Genetics; Personalized medicine; Targeted therapy; PHASE-II TRIAL; GROWTH-FACTOR RECEPTOR; DUCTAL ADENOCARCINOMA; 1ST-LINE TREATMENT; PLUS GEMCITABINE; OPEN-LABEL; K-RAS; MUTATIONS; TRASTUZUMAB; KRAS;
D O I：
10.1016/j.suc.2016.07.014
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Over the past decade, emerging technologies have provided new insights into the genomic landscape of pancreatic ductal adenocarcinoma (PDA). In addition to the commonly recognized genetic drivers of pancreatic carcinogenesis (KRAS, CDKN2A, TP53, SMAD4), new genes and pathways have been implicated. However, these efforts have not identified any new high-frequency actionable mutations, limiting the success of mutation-targeted therapy in PDA. This article provides a report on the current landscape of pancreas cancer genetics and targeted therapeutics.
引用
收藏
页码：1207 / +
页数：16
相关论文
共 50 条
  • [31] ORIGIN OF CANCER METASTASES AND ITS IMPLICATIONS FOR THERAPY
    FIDLER, IJ
    ISRAEL JOURNAL OF MEDICAL SCIENCES, 1988, 24 (9-10): : 456 - 463
  • [32] Autophagy in breast cancer and its implications for therapy
    Jain, Kirti
    Paranandi, Krishna S.
    Sridharan, Savitha
    Basu, Alakananda
    AMERICAN JOURNAL OF CANCER RESEARCH, 2013, 3 (03): : 251 - 265
  • [33] Impact of exosome therapy on pancreatic cancer and its progression
    El-Tanani, Mohamed
    Nsairat, Hamdi
    Matalka, Ismail I.
    Aljabali, Alaa A. A.
    Mishra, Vijay
    Mishra, Yachana
    Naikoo, Gowhar A.
    Chava, Sai Raghuveer
    Charbe, Nitin B.
    Tambuwala, Murtaza M.
    MEDICAL ONCOLOGY, 2023, 40 (08)
  • [34] Impact of exosome therapy on pancreatic cancer and its progression
    Mohamed El-Tanani
    Hamdi Nsairat
    Ismail I. Matalka
    Alaa A. A. Aljabali
    Vijay Mishra
    Yachana Mishra
    Gowhar A. Naikoo
    Sai Raghuveer Chava
    Nitin B. Charbe
    Murtaza M. Tambuwala
    Medical Oncology, 40
  • [35] The dendritic therapy with its potential applications in pancreatic cancer
    Van Gool, S.
    ACTA GASTRO-ENTEROLOGICA BELGICA, 2009, 72 (03) : 338 - 343
  • [36] The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy
    Zhong, Xiaoling
    Pons, Marianne
    Poirier, Christophe
    Jiang, Yanlin
    Liu, Jianguo
    Sandusky, George E.
    Shahda, Safi
    Nakeeb, Attila
    Schmidt, C. Max
    House, Michael G.
    Ceppa, Eugene P.
    Zyromski, Nicholas J.
    Liu, Yunlong
    Jiang, Guanglong
    Couch, Marion E.
    Koniaris, Leonidas G.
    Zimmers, Teresa A.
    JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2019, 10 (05) : 1083 - 1101
  • [37] Pancreatic cancer stem cell biology and its therapeutic implications
    Filip Bednar
    Diane M. Simeone
    Journal of Gastroenterology, 2011, 46 : 1345 - 1352
  • [38] The KRAS mutational spectrum and its clinical implications in pancreatic cancer
    Perelli, Luigi
    Genovese, Giannicola
    Draetta, Giulio F.
    CANCER CELL, 2024, 42 (09) : 1494 - 1496
  • [39] Pancreatic cancer stem cell biology and its therapeutic implications
    Bednar, Filip
    Simeone, Diane M.
    JOURNAL OF GASTROENTEROLOGY, 2011, 46 (12) : 1345 - 1352
  • [40] The implications of genetics in colorecatal cancer
    Mecklin, J. -P.
    ANNALS OF ONCOLOGY, 2008, 19 : 87 - 90
12345