Intercellular communication: diverse structures for exchange of genetic information

被引：520
|
作者：
Mittelbrunn, Maria [3 ]
Sanchez-Madrid, Francisco [1 ,2 ]
机构：
[1] Univ Autonoma Madrid, Ctr Nacl Invest Cardiovasc, Madrid 28006, Spain
[2] Univ Autonoma Madrid, Inst Invest Sanitaria Hosp Princesa, Madrid 28006, Spain
[3] Ctr Nacl Invest Cardiovasc, Madrid 28029, Spain
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 05期
关键词：
CELL-TO-CELL; ENDOTHELIAL-CELLS; IMMUNOLOGICAL SYNAPSE; HORIZONTAL TRANSFER; MEMBRANE NANOTUBES; MESSENGER-RNAS; SILENCING RNAS; MICRORNAS; REQUIRES; DELIVERY;
D O I：
10.1038/nrm3335
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
An emerging concept is that cellular communication in mammals can be mediated by the exchange of genetic information, mainly in the form of microRNAs. This can occur when extracellular vesicles, such as exosomes, secreted by a donor cell are taken up by an acceptor cell. Transfer of genetic material can also occur through intimate membrane contacts between donor and acceptor cells. Specialized cell-cell contacts, such as synapses, have the potential to combine these modes of genetic transfer.
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页码：328 / 335
页数：8
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