Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

被引:238
|
作者
Fan, W [1 ]
Ellacott, KLJ [1 ]
Halatchev, IG [1 ]
Takahashi, K [1 ]
Yu, PX [1 ]
Cone, RD [1 ]
机构
[1] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97239 USA
关键词
D O I
10.1038/nn1214
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.
引用
收藏
页码:335 / 336
页数:2
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