MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia

被引：66
|
作者：
Moqadam, F. Akbari [1 ]
Lange-Turenhout, E. A. M. [1 ]
Aries, I. M. [1 ]
Pieters, R. [1 ]
den Boer, M. L. [1 ]
机构：
[1] Univ Med Ctr Rotterdam, Dept Pediat Oncol & Hematol, Erasmus MC Sophia Childrens Hosp, Rotterdam, Netherlands
来源：
LEUKEMIA RESEARCH | 2013年 / 37卷 / 10期
关键词：
Leukemia; miRNA; Vincristine resistance; miR-125b; miR-99a; miR-100; HEMATOPOIETIC STEM-CELLS; ANTAGONIST KILLER 1; DRUG-RESISTANCE; EXPRESSION PROFILES; MESSENGER-RNAS; CANCER CELLS; MICRORNAS; CONFERS; APOPTOSIS; DIFFERENTIATION;
D O I：
10.1016/j.leukres.2013.06.027
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNA-125b (miR-125b), miR-99a and miR-100 are overexpressed in vincristine-resistant acute lymphoblastic leukemia (ALL). Cellular viability of ETV6-RUNX1-positive Reh cells significantly increased in presence of 9 ng/mL vincristine upon co-expression of miR-125b/miR-99a (91 +/- 4%), miR-125b/miR-100 (93 +/- 5%) or miR-125b/miR-99a/miR-100 (82 +/- 17%) compared with miR-125b-transduced cells (38 +/- 13%, P < 0.05). Co-expression of these miRNAs resulted in downregulation of DNTT, NUCKS1, MALAT1, SNRPE, PNO1, SET, KIF5B, PRPS2, RPS11, RPL38 and RPL23A (fold-change 1.3-1.9, p < 0.05). Similarly, 7 out of these genes are lower expressed in vincristine-resistant ALL cells of children (p < 0.05). The concerted function of miR-125b in combination with miR-99a and/or miR-100 illustrates the complexity of vincristine-resistant pediatric ALL. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1315 / 1321
页数：7
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