Discordant courses of COVID-19 in a cohabiting couple of lung transplant recipients

被引:5
|
作者
Desmazes-Dufeu, Nadine [1 ]
Coltey, Berengere [1 ]
Amari, Lyria [1 ]
Gouitaa, Marion [2 ]
Touzery, Camille [3 ]
Reynaud-Gaubert, Martine [1 ,4 ]
Chanez, Pascal [2 ]
Cassir, Nadim [4 ]
机构
[1] Hop Nord Marseille, Assistance Publ Hop Marseille AP HM, Serv Pneumol, Equipe Transplantat Pulmonaire, Marseille, France
[2] Aix Marseille Univ, AP HM, Clin Bronches Allergie & Sommeil, Marseille C2VN Ctr INSERM INRAE UMR1062, Marseille, France
[3] Hop Nord Marseille, AP HM, Serv Radiol, Marseille, France
[4] Aix Marseille Univ UM63, Assistance Publ Hop Marseille AP HM, Microbes Evolut Phylogeny & Infect MEI, Inst Rech Dev IRD 198, 19-21 Blvd Jean Moulin, F-13005 Marseille, France
关键词
COVID-19; cystic fibrosis; immunosuppression; lung transplant; SARS-CoV-2; viral pneumonia;
D O I
10.1111/tid.13410
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
COVID-19 is a novel infectious disease caused by SARS-CoV-2 that emerged in late 2019 and which is now a pandemic. Solid organ transplant recipients are perceived to be at increased risk of severe COVID-19 due to their chronic use of immunosuppressive drugs (ISDs) and to their associated conditions. Scarce data are available on the optimized management of ISDs in these patients and on its impact on presentation, clinical course, viral shedding, and outcome. We report here two cases of COVID-19 in a cohabiting couple of lung transplant recipients for cystic fibrosis, who had different ISDs management and who developed discordant courses of their disease. Our findings suggest that the degree of their immunosuppression might be a reason for their different course and that ISDs might prove partially protective.
引用
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页数:5
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