Synthesis and Evaluation of Some Novel 2-Amino-4-Aryl Thiazoles for Antitubercular Activity

被引：13
|
作者：
Gundlewad, Gangadhar B. [1 ]
Patil, Bhagwan R. [2 ]
机构：
[1] Shri Shivaji Coll, Dept Chem, Parbhani 431401, Maharashtra, India
[2] Sharda Mahavidyalaya, Dept Chem, Parbhani 431401, Maharashtra, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 03期
关键词：
EFFICIENT SYNTHESIS; RECEPTOR LIGANDS; DERIVATIVES; AGENTS; INHIBITORS;
D O I：
10.1002/jhet.3098
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel 2-amino-4-aryl thiazoles were synthesized from -chloroacetophenone and thiourea at room temperature using acetone as solvent. The structures of synthesized compounds were confirmed by spectral data. All the compounds were evaluated for antitubercular activity by macro broth dilution method against Mycobacterium Tuberculosis H37Rv as standard strain. The synthesized compound displays notable antitubercular activity.
引用
收藏
页码：769 / 774
页数：6
相关论文
共 50 条
  • [1] Synthesis and biological evaluation of some 2-amino-4-aryl thiazoles and their thiazolylamides
    Agarwal, N
    Kumar, S
    Shrivastava, AK
    Sarkar, PC
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 1997, 6 (04) : 291 - 294
  • [2] Synthesis and biological activity of some 2-aryl-4-coumarino-thiazoles
    Kalluraya, B
    Chimbalkar, R
    Vishwanatha, P
    Kotian, M
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 1995, 5 (02) : 153 - 154
  • [3] SYNTHESIS AND CHARACTERIZATION OF SOME 2-AMINO-4-ARYL-5-ARYLAZO SUBSTITUTED THIAZOLES
    GOYAL, RN
    MINOCHA, A
    POLISH JOURNAL OF CHEMISTRY, 1985, 59 (01) : 79 - 84
  • [4] Synthesis and Antitubercular Activity of Some Novel Schiff's Bases of 2-Amino-5-Aryl-1,3,4-Oxadiazoles
    Harish, Rajak
    Kumar, Gupta Arun
    RESEARCH JOURNAL OF CHEMISTRY AND ENVIRONMENT, 2009, 13 (04): : 56 - 62
  • [5] Synthesis and antitubercular activity of imidazo[2,1-b] thiazoles
    Andreani, A
    Granaiola, M
    Leoni, A
    Locatelli, A
    Morigi, R
    Rambaldi, M
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2001, 36 (09) : 743 - 746
  • [6] Synthesis and evaluation of antitubercular activity of fluorinated 5-aryl-4-(hetero)aryl substituted pyrimidines
    Verbitskiy, Egor V.
    Baskakova, Svetlana A.
    Kravchenko, Marionella A.
    Skornyakov, Sergey N.
    Rusinov, Gennady L.
    Chupakhin, Oleg N.
    Charushin, Valery N.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (16) : 3771 - 3780
  • [7] Synthesis and Antitubercular Activity of Novel Amino Acid Derivatives
    Da Costa, Cristiane F.
    Pinheiro, Alessandra C.
    De Almeida, Mauro V.
    Lourenco, Maria C. S.
    De Souza, Marcus V. N.
    CHEMICAL BIOLOGY & DRUG DESIGN, 2012, 79 (02) : 216 - 222
  • [8] MNPs@SiO2-Pr-AP: A new catalyst for the synthesis of 2-amino-4-aryl thiazole derivatives
    Ghorbani-Vaghei, Ramin
    Alavinia, Sedigheh
    Merati, Zohreh
    Izadkhah, Vida
    APPLIED ORGANOMETALLIC CHEMISTRY, 2018, 32 (03)
  • [9] Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyranopyrimidines
    Kamdar, Nimesh R.
    Haveliwala, Dhaval D.
    Mistry, Prashant T.
    Patel, Saurabh K.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (11) : 5056 - 5063
  • [10] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 2-AMINO-4-ARYL-5-CHROMANYLAZOTHIAZOLES
    AHLUWALIA, VK
    SINGH, RP
    SINGH, RP
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1987, 26 (03): : 287 - 289
12345