Nucleosome autoantibodies

被引：23
|
作者：
Decker, P [1 ]
机构：
[1] Univ Tubingen, Dept Immunol, Inst Cell Biol, D-72076 Tubingen, Germany
来源：
CLINICA CHIMICA ACTA | 2006年 / 366卷 / 1-2期
关键词：
nucleosome; autoantibodies; autoantigens; systemic lupus erythematosus; pathogenicity;
D O I：
10.1016/j.cca.2005.11.009
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The nucleosome is a large protein-nucleic acid complex involved in DNA packing and in controlling genetic information. Under circumstances described below, this component, normally sequestered in the cell nucleus, is released into the extracellular milieu and then is easily accessible to cells of the immune system. For still not completely understood reasons, nucleosomes become immunogenic under particular conditions. Thus, anti-nucleosome autoantibodies (autoAb) have been described in connective tissue diseases and especially in systemic lupus erythematosus (SLE). This review describes the mechanisms leading to nucleosome production and anti-nucleosome autoimmunity, as well as the pathogenesis associated with nucleosomes. (c) 2005 Elsevier B.V. All rights reserved.
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页码：48 / 60
页数：13
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