Study on the Secondary Metabolites of the Endophytic Fungus Aspergillus terreus HQ100X-1 in Scutellaria formosana

被引：2

作者：

Huang, Dan ^{[1
,2
]}

Nong, Xuhua ^{[1
,2
]}

Yang, Jianni ^{[1
,2
]}

Li, Chen ^{[1
,2
]}

Han, Changri ^{[3
]}

Chen, Guangying ^{[1
,2
]}

Song, Xiaoping ^{[1
,2
]}

Sun, Zhenfan ^{[3
]}

Hui, Yang ^{[1
,2
]}

Chen, Wenhao ^{[1
,2
]}

机构：

[1] Hainan Normal Univ, Key Lab Trop Med Resource Chem, Minist Educ, Coll Chem & Chem Engn, Haikou 571158, Hainan, Peoples R China

[2] Hainan Normal Univ, Key Lab Trop Med Plant Chem Hainan Prov, Coll Chem & Chem Engn, Haikou 571158, Hainan, Peoples R China

[3] Hainan Vocat Univ Sci & Technol, Key Lab Med & Edible Plants Resources Hainan Prov, Haikou 571126, Hainan, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 42卷 / 09期

基金：

海南省自然科学基金; 中国国家自然科学基金;

关键词：

scutellaria formosana; Aspergillus terreus; antibacterial activity; NEOCLERODANE DITERPENOID ALKALOIDS; BARBATA; BUTENOLIDES; DERIVATIVES;

D O I：

10.6023/cjoc202202016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new compounds, terrustone (1) and asperteretone G (2) together with ten known compounds were isolated from Scutellaria formosana endophytic fungus Aspergillus terreus HQ100X-1, terrustone (1) is a trihydroxycyclopentanone with four consecutive chiral centers. Their structures were determined by 1D/2D NMR data along with electrostatic circular dichroism (ECD) calculation for configurational assignment. Compound rbrolide R (4) showed antibacterial activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) value of 2.5 mu g/mL.

引用

页码：2961 / 2966

页数：6

共 23 条

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