Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population

被引：14
|
作者：
Takahashi, N
Ishihara, R
Saito, S
Maemo, N
Aoyama, N
Ji, XF
Miura, H
Ikeda, M
Iwata, N
Suzuki, T
Kitajima, T
Yamanouchi, Y
Kinoshita, Y
Ozaki, N
Inada, T
机构：
[1] Teikyo Univ, Ichihara Hosp, Sch Med, Dept Psychiat, Chiba 2990111, Japan
[2] Nagoya Univ, Grad Sch Med, Dept Psychiat, Nagoya, Aichi, Japan
[3] Nagoya Univ, Grad Sch Med, Dept Med Technol, Nagoya, Aichi, Japan
来源：
SCHIZOPHRENIA RESEARCH | 2006年 / 83卷 / 2-3期
关键词：
chromogranin A; schizophrenia; gene; haplotype; association;
D O I：
10.1016/j.schres.2005.12.854
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p=0.0269), and with a 2 marker haplotype (p=0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：179 / 183
页数：5
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