Palladium-Catalyzed Multicomponent Synthesis of Fully Substituted Alkylidene Furanones

被引：9

作者：

Renteria-Gomez, Angel ^{[1
]}

Torres-Ochoa, Ruben O. ^{[2
]}

Gamez-Montano, Rocio ^{[3
]}

Wang, Qian ^{[1
]}

Zhu, Jieping ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Synth & Nat Prod, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland

[2] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Mexico City 04510, DF, Mexico

[3] Univ Guanajuato, Dept Quim, Div Ciencias Nat & Exactas, Guanajuato 36050, Mexico

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 17期

基金：

瑞士国家科学基金会;

关键词：

DOMINO REACTION; 3(2H)-FURANONES; CYCLIZATION; DERIVATIVES; NITRILES; ANNULATION; ALKENES; YNONES; ACIDS; HETEROANNULATION;

D O I：

10.1021/acs.orglett.0c02578

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of a catalytic amount of Pd(OAc)(2) and XantPhos, the three-component reaction of ynones, imines, and aryl iodides affords fully substituted alkylidene-furan-3(2H)-ones via a sequence of the Mannich reaction followed by chemo- and regioselective oxypalladation and reductive elimination. One carbon-oxygen and two carbon-carbon bonds are generated to afford the heterocycle in good to excellent yield.

引用

页码：7030 / 7033

页数：4

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