Genetic diversity of HLA system in two populations from Morelos, Mexico: Cuernavaca and rural Morelos

被引：2

作者：

Ortega-Yanez, Andrea ^{[1
]}

Barquera, Rodrigo ^{[2
,3
]}

Curiel-Giles, Laura ^{[4
]}

Cesar Martinez-Alvarez, Julio ^{[5
]}

Maria Macias-Medrano, Rosa ^{[6
]}

Arrieta-Bolanos, Esteban ^{[7
]}

Clayton, Stephen ^{[2
]}

Bravo-Acevedo, Alicia ^{[8
]}

Iraiz Hernandez-Zaragoza, Diana ^{[3
,9
]}

Immel, Alexander ^{[2
,10
]}

del Rosario Vega-Martinez, Maria ^{[11
]}

Benitez-Arvizu, Gamaliel ^{[12
]}

Araceli Arrazola-Garcia, Maria ^{[5
]}

Jerico Arriaga-Perea, Agustin ^{[6
]}

Dolores Juarez-Cortes, Eva ^{[6
]}

Juarez-Barreto, Vicencio ^{[13
]}

Salgado-Galicia, Norma ^{[11
]}

Novelo-Garza, Barbara ^{[14
]}

Zuniga, Joaquin ^{[15
,16
]}

Yunis, Edmond J. ^{[17
]}

Bekker-Mendez, Carolina ^{[18
]}

Granados, Julio ^{[19
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Biotecnol IBT, Dept Dev Genet & Mol Physiol, Cuernavaca, Morelos, Mexico

[2] Max Planck Inst Sci Human Hist, Dept Archaeogenet, Kahlaische Str 10, D-07745 Jena, Germany

[3] Escuela Nacl Antropol & Hist ENAH, Mol Genet Lab, Mexico City, DF, Mexico

[4] Fiscalia Gen Estado Morelos, Forens Anthropol Area, Cuenavaca, Morelos, Mexico

[5] Inst Mexicano Seguro Social IMSS, Unidad Med Alta Especialidad UMAE Ctr Med Nacl Si, Hosp Especialidades, HLA Lab,Cent Blood Bank, Mexico City, DF, Mexico

[6] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl La Raza, Histocompatibil Lab, Cent Blood Bank, Mexico City, DF, Mexico

[7] Univ Hosp Essen, Inst Expt Cellular Therapy, Essen, Germany

[8] Inst Mexicano Seguro Social IMSS, UMAE Hosp Gineco Obstet 4 Luis Castelazo Ayala, Blood Bank, Mexico City, DF, Mexico

[9] Tecn Genet Aplicadas Clin TGAC, Immunogenet Unit, Mexico City, DF, Mexico

[10] Univ Kiel, Univ Hosp, Inst Clin Mol Biol IKMB, Schleswig Holstein, Germany

[11] Hosp Cent Sur Alta Especialidad, Mol Biol & Histocompatibil Lab, Petroleos Mexicanos PEMEX, Mexico City, DF, Mexico

[12] Inst Mexicano Seguro Social IMSS, Unidad Med Alta Especialidad UMAE Ctr Med Nacl Si, Hosp Especialidades, Cent Blood Bank, Mexico City, DF, Mexico

[13] Hosp Infantil Mexico Dr Federico Gomez, Blood Bank, Mexico City, DF, Mexico

[14] Inst Mexicano Seguro Social IMSS, Med Infrastruct Planning Comm, Mexico City, DF, Mexico

[15] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Lab Immunobiol & Genet, Mexico City, DF, Mexico

[16] Tecnol Monterrey, Escuela Med & Ciencias Salud, Mexico City, DF, Mexico

[17] Dana Farber Canc Inst, Dept Canc Immunol & Virol, Boston, MA 02115 USA

[18] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl La Raza, Infectol Hosp, Immunol & Infectol Res Unit, Mexico City, DF, Mexico

[19] Inst Nacl Ciencias Med & Nutr Salvador Zubiran IN, Dept Transplantat, Mexico City, DF, Mexico

来源：

HUMAN IMMUNOLOGY | 2020年 / 81卷 / 09期

关键词：

HLA; Immunogenetics; Population genetics; Morelos; Admixture;

D O I：

10.1016/j.humimm.2019.07.289

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 112 Mexicans from the state of Morelos living in the city of Cuernavaca (N = 82) and rural communities (N = 30), to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes in Morelos include seven Native American, one European, one African and one Asian haplotype. Admixture estimates revealed that the main genetic components in Morelos are Native American (60.43 +/- 2.22% by ML; 53.57% of Native American haplotypes) and European (39.58 +/- 3.70% by ML; 27.68% of European haplotypes), and a virtually absent African genetic component (0.00 +/- 4.93% by ML; but 11.16% of African haplotypes).

引用

页码：557 / 559

页数：3

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