A BIFUNCTIONAL TUMOR ACTIVATED IMMUNOMODULATOR (TRACIR) TARGETING PD-L1 AND CD28 IS A POTENT ENHANCER OF T CELL-MEDIATED ANTI-TUMOR ACTIVITY

被引：0

作者：

DiRaimondo, Thomas ^{[1
]}

Budimir, Natalija ^{[1
]}

Ma, Lina ^{[1
]}

Shenhav, Simon ^{[1
]}

Cicchini, Vanessa ^{[1
]}

Navert, Robert ^{[1
]}

Wu, Hua ^{[1
]}

Jocic, Renee ^{[1
]}

Yu, Cuiling ^{[1
]}

Aceveda, Diane ^{[1
]}

Best, Hannah ^{[1
]}

Prentiss, Clara ^{[1
]}

Muskat, Kai ^{[1
]}

Chang, Jason ^{[1
]}

Dastmalchi, Farhad ^{[1
]}

Roup, Fabrece ^{[1
]}

Caffaro, Carolina ^{[1
]}

Aerni, Hans ^{[1
]}

Godfrey, Wayne ^{[1
]}

Winter, Charles ^{[1
]}

Nasoff, Marc ^{[1
]}

Gibson, Neil ^{[1
]}

Campbell, David ^{[1
]}

Salek-Ardakan, Shahram ^{[1
]}

机构：

[1] Janux Therapeut, San Diego, CA USA

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2022年 / 10卷

关键词：

D O I：

10.1136/jitc-2022-SITC2022.1326

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1326

引用

页码：A1377 / A1377

页数：1

共 50 条

[21] Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway
Fenwick, Craig
Loredo-Varela, Juan-Luis
Joo, Victor
Pellaton, Celine
Farina, Alex
Rajah, Navina
Esteves-Leuenberger, Line
Decaillon, Thibaut
Suffiotti, Madeleine
Noto, Alessandra
Ohmiti, Khalid
Gottardo, Raphael
Weissenhorn, Winfried
Pantaleo, Giuseppe
JOURNAL OF EXPERIMENTAL MEDICINE, 2019, 216 (07): : 1525 - 1541
[22] Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation
Xu, Xiaoyan
Xie, Tingxue
Zhou, Mengxin
Sun, Yaqin
Wang, Fengqi
Tian, Yanan
Chen, Ziyan
Xie, Yanqi
Wu, Ronghai
Cen, Xufeng
Zhou, Jichun
Hou, Tingjun
Zhang, Lei
Huang, Chaoyang
Zhao, Qingwei
Wang, Dongrui
Xia, Hongguang
NATURE COMMUNICATIONS, 2024, 15 (01)
[23] ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
Youqian Wu
Chao Zhang
Xiaolan Liu
Zhengfu He
Bing Shan
Qingxin Zeng
Qingwei Zhao
Huaying Zhu
Hongwei Liao
Xufeng Cen
Xiaoyan Xu
Mengmeng Zhang
Tingjun Hou
Zhe Wang
Huanhuan Yan
Shuying Yang
Yaqin Sun
Yanying Chen
Ronghai Wu
Tingxue Xie
Wei Chen
Ayaz Najafov
Songmin Ying
Hongguang Xia
Nature Communications, 12
[24] Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation
Shi, Chengyu
Wang, Ying
Wu, Minjie
Chen, Yu
Liu, Fangzhou
Shen, Zheyuan
Wang, Yiran
Xie, Shaofang
Shen, Yingying
Sang, Lingjie
Zhang, Zhen
Gao, Zerui
Yang, Luojia
Qu, Lei
Yang, Zuozhen
He, Xinyu
Guo, Yu
Pan, Chenghao
Che, Jinxin
Ju, Huaiqiang
Liu, Jian
Cai, Zhijian
Yan, Qingfeng
Yu, Luyang
Wang, Liangjing
Dong, Xiaowu
Xu, Pinglong
Shao, Jianzhong
Liu, Yang
Li, Xu
Wang, Wenqi
Zhou, Ruhong
Zhou, Tianhua
Lin, Aifu
NATURE COMMUNICATIONS, 2022, 13 (01)
[25] Tumor Endothelial Cell-Mediated Antigen-Specific T-cell Suppression via the PD-1/PD-L1 Pathway
Taguchi, Kazuhiro
Onoe, Takashi
Yoshida, Tomoaki
Yamashita, Yoshinori
Tanaka, Yuka
Ohdan, Hideki
MOLECULAR CANCER RESEARCH, 2020, 18 (09) : 1427 - 1440
[26] ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
Wu, Youqian
Zhang, Chao
Liu, Xiaolan
He, Zhengfu
Shan, Bing
Zeng, Qingxin
Zhao, Qingwei
Zhu, Huaying
Liao, Hongwei
Cen, Xufeng
Xu, Xiaoyan
Zhang, Mengmeng
Hou, Tingjun
Wang, Zhe
Yan, Huanhuan
Yang, Shuying
Sun, Yaqin
Chen, Yanying
Wu, Ronghai
Xie, Tingxue
Chen, Wei
Najafov, Ayaz
Ying, Songmin
Xia, Hongguang
NATURE COMMUNICATIONS, 2021, 12 (01)
[27] Tumor endothelial cell-mediated antigen-specific T-cell suppression via the PD-1/PD-L1 pathway
Taguchi, Kazuhiro
Onoe, Takashi
Tashiro, Hirotaka
Ohdan, Hideki
CANCER SCIENCE, 2021, 112 : 402 - 402
[28] Design, synthesis, anti-tumor activity and mechanism of novel PROTACs as degraders of PD-L1 and inhibitors of PD-1/PD-L1 interaction
Zhang, Feng
Yu, Qimeng
Wu, Caiyun
Sun, Shishi
Wang, Yu
Wang, Rui
Chen, Zejie
Zhang, Hua
Xiong, Xuqiong
Awadasseid, Annoor
Rao, Guowu
Zhao, Xiaoyin
Zhang, Wen
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 111
[29] A novel immunocytokine generates a CD8+T cell-mediated anti-tumor response in vivo
Fallon, Jonathan K.
Tighe, Robert
Strittmatter, Wolfgang
Sabzevari, Helen
Schlom, Jeffrey
Greiner, John W.
CANCER RESEARCH, 2012, 72
[30] HDAC inhibition potentiates anti-tumor activity of macrophages and enhances anti-PD-L1-mediated tumor suppression
Xiaolei Li
Xiao Su
Rui Liu
Yongsha Pan
Jiankai Fang
Lijuan Cao
Chao Feng
Qianwen Shang
Yongjing Chen
Changshun Shao
Yufang Shi
Oncogene, 2021, 40 : 1836 - 1850

← 1 2 3 4 5 →