Amitorin, a Cytotoxic Diterpenoid from a Sponge Halichondria sp

被引：1
|
作者：
Wauke, Tsuyoshi [1 ]
Hanif, Novriyandi [2 ]
Ohlinger, Sean [3 ]
de Voogd, Nicole Joy [4 ,5 ]
Kurnianda, Viqqi [1 ]
Jomori, Takahiro [1 ]
Tanaka, Junichi [1 ]
机构：
[1] Univ Ryukyus, Dept Chem Biol & Marine Sci, Nishihara, Okinawa 9030213, Japan
[2] IPB Univ, Fac Math & Nat Sci, Dept Chem, Bogor 16680, Indonesia
[3] Wavefunction Inc, 18401 Von Karman Ave,Suite 435, Irvine, CA 92612 USA
[4] Nat Biodivers Ctr, NL-2300 RA Leiden, Netherlands
[5] Leiden Univ, Inst Environm Sci CML, Leiden, Netherlands
来源：
CHEMISTRY LETTERS | 2022年 / 51卷 / 11期
关键词：
Marine natural products; Sponge; Endoperoxide;
D O I：
10.1246/cl.220371
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new diterpenoid endoperoxide showing cytotoxicity named amitorin (1) was isolated from an extract of a sponge Halichondria sp. Its structure along with relative stereochem-istry was elucidated with spectral analysis and calculation studies. The structure and cytotoxicity (IC50 2.3 over bar M against NBT-II cells) of the molecule are described herein.
引用
收藏
页码：1080 / 1082
页数：3
相关论文
共 50 条
  • [31] CYLINDRAMIDE - CYTOTOXIC TETRAMIC ACID LACTAM FROM THE MARINE SPONGE HALICHONDRIA-CYLINDRATA TANITA AND HOSHINO
    KANAZAWA, S
    FUSETANI, N
    MATSUNAGA, S
    TETRAHEDRON LETTERS, 1993, 34 (06) : 1065 - 1068
  • [32] Cytotoxic alkaloids from the marine sponge Thorectandra sp.
    Charan, RD
    Mckee, TC
    Boyd, MR
    NATURAL PRODUCT RESEARCH, 2004, 18 (03) : 225 - 229
  • [33] Cytotoxic Petrosiacetylenes from the Marine Sponge Petrosia sp.
    Lee, Yeon-Ju
    Yoo, Su-Jung
    Kang, Jong Soon
    Yun, Jieun
    Shin, Hee Jae
    Lee, Jong Seok
    Lee, Hyi-Seung
    LIPIDS, 2013, 48 (01) : 87 - 91
  • [34] NEW CYTOTOXIC SESTERTERPENES FROM THE MARINE SPONGE SPONGIA SP
    HE, HY
    KULANTHAIVEL, P
    BAKER, BJ
    TETRAHEDRON LETTERS, 1994, 35 (39) : 7189 - 7192
  • [35] Cytotoxic metabolites from an Indonesian sponge Lendenfeldia sp.
    Dai, Jingqiu
    Liu, Yang
    Zhou, Yu-Dong
    Nagle, Dale G.
    JOURNAL OF NATURAL PRODUCTS, 2007, 70 (11): : 1824 - 1826
  • [36] Cytotoxic furanosesterterpenes from a marine sponge Psammocinia sp.
    Choi, K
    Hong, JK
    Lee, CO
    Kim, DK
    Sim, CJ
    Im, KS
    Jung, JH
    JOURNAL OF NATURAL PRODUCTS, 2004, 67 (07): : 1186 - 1189
  • [37] Arsenic compounds in marine sponge (Haliclona permolis, Halichondria japonica, Halichondria okadai and Haliclona sp white) from Seto Inland Sea, Japan
    Yamaoka, Y
    Carmona, ML
    Oclarit, JM
    Jin, KZ
    Shibata, Y
    APPLIED ORGANOMETALLIC CHEMISTRY, 2001, 15 (04) : 261 - 265
  • [38] Cytotoxic polyacetylenes from the marine sponge Petrosia sp.
    Kim, JS
    Lim, YJ
    Im, KS
    Jung, JH
    Shim, CJ
    Lee, CO
    Hong, J
    Lee, H
    JOURNAL OF NATURAL PRODUCTS, 1999, 62 (04): : 554 - 559
  • [39] Cytotoxic oxylipins from a marine sponge Topsentia sp.
    Luo, X
    Li, FM
    Hong, JK
    Lee, CO
    Sim, CJ
    Im, KS
    Jung, JH
    JOURNAL OF NATURAL PRODUCTS, 2006, 69 (04): : 567 - 571
  • [40] ASSOCIATION OF HETEROTROPHIC NITROGEN-FIXING BACTERIA WITH A MARINE SPONGE OF HALICHONDRIA SP
    SHIEH, WY
    LIN, YM
    BULLETIN OF MARINE SCIENCE, 1994, 54 (02) : 557 - 564
12345