Chemical Composition and Validation of the Ethnopharmacological Reported Antimicrobial Activity of the Body Fat of Phrynops geoffroanus Used in Traditional Medicine

被引：5

作者：

Dias, Diogenes de Queiroz ^{[1
]}

Santos Cabral, Mario Eduardo ^{[2
]}

Sales, Debora Lima ^{[3
]}

Oliveira, Olga Paiva ^{[1
]}

de Araujo Filho, Joao Antonio ^{[4
]}

Teles, Diego Alves ^{[1
]}

Goncalves de Sousa, Jose Guilherme ^{[1
]}

Melo Coutinho, Henrique Douglas ^{[1
]}

Martins da Costa, Jose Galberto ^{[1
]}

Kerntopf, Marta Regina ^{[1
]}

da Nobrega Alves, Romulo Romeu ^{[5
]}

Almeida, Waltecio de Oliveira ^{[1
]}

机构：

[1] Univ Reg Cariri, Programa Posgrad Bioprospeccao Mol, BR-63105000 Crato, CE, Brazil

[2] Univ Fed Ceara, Programa Posgrad Biotecnol Recursos Nat, BioMol Lab, Dept Bioquim & Biol Mol, BR-60455970 Fortaleza, Ceara, Brazil

[3] Univ Fed Rural Pernambuco UFRPE, Programa Posgrad Etnobiol & Conservacao Nat, BR-52171900 Recife, PE, Brazil

[4] Univ Reg Cariri, Dept Quim Biol, BR-63105000 Crato, CE, Brazil

[5] Univ Estadual Paraiba, Dept Biol, BR-58429500 Campina Grande, PB, Brazil

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2013年 / 2013卷

关键词：

ANTIBACTERIAL; CAPTIVITY; CRATO;

D O I：

10.1155/2013/715040

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Background. Phrynops geoffroanus is a small turtle that inhabits lakes, rivers, and streams throughout South America. The body fat of this animal is used as a folk medicine in Brazil for treating illnesses such as sore throats, ear aches, mumps, rheumatism, and arthritis. The present study evaluated the antimicrobial activity of oil extracted from Phrynops geoffroanus (OPG), determined its chemical composition, and discussed the implications of its use in traditional medicine. The OPG was obtained from the ventral region of this turtle using hexane as a solvent. The antimicrobial activity of OPG was tested against standard and multiresistance strains of bacteria and fungi and its composition was determined indirectly by analyzing the methyl esters of the component fatty acids. The OPG presented a clinically relevant antifungal activity against Candida krusei ATCC 6258 (MIC 128 mu g/mL). When the OPG was associated with the antibacterial and antifungal drugs, was observed a synergistic effect when associated the OPG with the gentamicin against the strain Pseudomonas aeruginosa 22. Our results indicated that OPG has clinically relevant antifungal activity against C. krusei, and demonstrated synergetic antibacterial activity in combination with commercial antibiotics against Pseudomonas aeruginosa.

引用

页数：4