Targeted fluorescent probes for detection of oxidative stress in the mitochondria

被引：13

作者：

Yapici, Nazmiye B. ^{[1
]}

Mandalapu, Srinivas ^{[1
]}

Gibson, K. Michael ^{[2
]}

Bi, Lanrong ^{[1
]}

机构：

[1] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA

[2] Washington State Univ, Coll Pharm, Expt & Syst Pharmacol, Spokane, WA 99201 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 17期

关键词：

Mitochondria-targeting; Oxidative stress; Fluorescence probes; IMAGING HYDROGEN-PEROXIDE; LIVING CELLS; BETA; ISCHEMIA/REPERFUSION; DISORDERS; APOPTOSIS; AUTOPHAGY; FISSION; DISEASE; INJURY;

D O I：

10.1016/j.bmcl.2015.07.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mitochondrial oxidative stress has been implicated in aging, neurodegenerative diseases, diabetes, stroke, ischemia/reperfusion injury, age-related macular degeneration (AMD) and cancer. Recently, we developed two new mitochondria-targeting fluorescent probes, MitoProbes I/II, which specifically localize in mitochondria and employed both in vivo and in vitro for detection of mitochondrial oxidative stress. Here, we report the design and synthesis of these agents, as well as their utility for real-time imaging of mitochondrial oxidative stress in cells. Published by Elsevier Ltd.

引用

页码：3476 / 3480

页数：5

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