An access to 1,3-azasiline-fused quinolinones via oxidative heteroannulation involving silyl C(sp3)-H functionalization

被引：54

作者：

Wu, Li-Jun ^{[1
,2
]}

Yang, Yuan ^{[1
,2
]}

Song, Ren-Jie ^{[1
,2
]}

Yu, Jiang-Xi ^{[1
,2
]}

Li, Jin-Heng ^{[1
,2
,3
]}

He, De-Liang ^{[1
]}

机构：

[1] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

[2] Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Contro, Nanchang 330063, Jiangxi, Peoples R China

[3] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 11期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; RADICAL ADDITION/CYCLIZATION CASCADE; ACTIVATED ALKENES; PHARMACOLOGICAL-PROPERTIES; INTRAMOLECULAR SILYLATION; SELECTIVE ACTIVATION; CATALYTIC SYNTHESIS; REUPTAKE INHIBITOR; SILICON ANALOG; AMINO-ACIDS;

D O I：

10.1039/c7cc08996a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Mn-promoted intermolecular oxidative radical heteroannulation of N-(2-cyanoaryl)-acrylamides and tertiary silanes has been described, which provides an efficient route to produce silicon/nitrogen heterocycles, sila-analogues of the known carbon-based structural motifs prevalent in bioactive natural products, pharmaceuticals and materials. The reaction enables Si-incorporation by controlling accurately several chemical bond cleavage and formation processes. Moreover, this reaction represents a new one-step construction of 1,3-azasiline-fused quinolinones that was achieved via silyl C(sp(3))-H functionalization using an oxidative radical strategy.

引用

页码：1367 / 1370

页数：4

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