Accuracy of transient elastography in assessing liver fibrosis in chronic viral hepatitis: A multicentre, retrospective study

被引：69

作者：

Seo, Yeon Seok ^{[1
]}

Kim, Moon Young ^{[2
]}

Kim, Seung Up ^{[3
]}

Hyun, Bae Si ^{[4
]}

Jang, Jae Young ^{[5
]}

Lee, Jin Woo ^{[6
]}

Lee, Jung Il

Suh, Sang Jun ^{[7
]}

Park, Soo Young ^{[8
]}

Park, Hana ^{[9
]}

Jung, Eun Uk ^{[10
,11
]}

Kim, Byung Seok ^{[12
]}

Kim, In Hee ^{[13
]}

Lee, Tae Hee ^{[14
]}

Um, Soon Ho ^{[1
]}

Han, Kwang-Hyub ^{[3
]}

Kim, Sang Gyune ^{[15
]}

Paik, Soon Koo ^{[3
]}

Choi, Jong Young ^{[4
]}

Jeong, Soung Won ^{[5
]}

Jin, Young Joo ^{[6
]}

Lee, Kwan Sik ^{[3
]}

Yim, Hyung Joon ^{[7
]}

Tak, Won Young ^{[8
]}

Hwang, Seong Gyu ^{[9
]}

Lee, Youn Jae ^{[10
,11
]}

Lee, Chang Hyeong ^{[12
]}

Kim, Dae-Ghon ^{[13
]}

Kang, Young Woo ^{[14
]}

Kim, Young Seok ^{[15
]}

机构：

[1] Korea Univ, Coll Med, Inst Digest Dis & Nutr, Dept Internal Med,Div Gastroenterol & Hepatol, Seoul 136705, South Korea

[2] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea

[3] Yonsei Univ, Coll Med, Inst Gastroenterol, Dept Internal Med, Seoul 120749, South Korea

[4] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med,Div Hepatol, Seoul, South Korea

[5] Soonchunhyang Univ, Coll Med, Ctr Digest Dis, Inst Digest Res,Dept Internal Med,Div Gastroenter, Seoul, South Korea

[6] Inha Univ, Sch Med, Dept Internal Med, Div Hepatol, Inchon, South Korea

[7] Korea Univ, Ansan Hosp, Dept Internal Med, Ansan, South Korea

[8] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Coll Med, Dept Internal Med, Daegu, South Korea

[9] CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Bundang, South Korea

[10] Inje Univ, Busan Paik Hosp, Coll Med, Dept Internal Med, Busan, South Korea

[11] Inje Univ, Busan Paik Hosp, Coll Med, Dept Prevent Med, Busan, South Korea

[12] Catholic Univ Daegu, Sch Med, Dept Internal Med, Daegu, South Korea

[13] Chonbuk Natl Univ, Med Sch & Hosp, Dept Internal Med, Seoul, South Korea

[14] Konyang Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Daejeon, South Korea

[15] Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Bucheon 420767, South Korea

来源：

LIVER INTERNATIONAL | 2015年 / 35卷 / 10期

关键词：

chronic liver disease; cirrhosis; Fibroscan; liver fibrosis; liver stiffness; performance; Transient elastography; STIFFNESS MEASUREMENT; ALANINE AMINOTRANSFERASE; PORTAL-HYPERTENSION; CIRRHOSIS; PERFORMANCE; PREDICTION; UPDATE; BIOPSY;

D O I：

10.1111/liv.12808

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/AimsTransient elastography (TE) has become an alternative to liver biopsy (LB). This study investigated the diagnostic performance of liver stiffness (LS) measurement using TE in Korean patients with chronic hepatitis B and C (CHB and CHC). MethodsFrom April 2006 to June 2014, 916 patients (567 CHB and 349 CHC) who underwent LB and TE at 15 centres were analyzed. The Batts and Ludwig scoring system was used for histologic assessment. Aspartate aminotransferase (AST)-to-platelet ratio indexes (APRI) were calculated. Area under the receiver operating characteristic curve (AUROC) was used. ResultsThe median age, LS value, and APRI score were 45years, 8.8kPa, and 0.61, respectively, in CHB patients vs. 51years, 6.8kPa and 0.55, respectively, in CHC patients. TE was significantly superior to APRI in CHB patients (AUROC 0.774 vs. 0.72 for F2, 0.849 vs. 0.812 for F3, and 0.902 vs. 0.707 for F4, respectively; all P<0.05). Furthermore, TE was significantly superior for predicting F3 stage (AUROC 0.865 vs. 0.840, P=0.009) whereas it was similar for predicting F2 and F4 stage (AUROC 0.822 vs. 0.796; 0.910 vs. 0.884; all P>0.05) in CHC patients. In CHB patients, optimal cut-off LS values were 7.8kPa for F2, 8.2kPa for F3, and 11.6kPa for F4, vs. 6.8kPa, 8.6kPa, and 14.5kPa, respectively, in CHC patients. ConclusionsTE can accurately assess the degree of liver fibrosis in Korean patients with CVH. TE was superior to APRI for predicting each fibrosis stage.

引用

页码：2246 / 2255

页数：10

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