Targeting Angiogenesis as a Promising Modality for the Treatment of Prostate Cancer

被引：9
|
作者：
Lin, Jianqing [1 ]
Kelly, William K. [1 ]
机构：
[1] Thomas Jefferson Univ, Jefferson Kimmel Canc Ctr, Dept Med Oncol, Philadelphia, PA 19107 USA
来源：
UROLOGIC CLINICS OF NORTH AMERICA | 2012年 / 39卷 / 04期
关键词：
Antiangiogenic therapy; Prostate cancer; Angiogenesis; Treatment; ENDOTHELIAL GROWTH-FACTOR; PHASE-II TRIAL; TUMOR ANGIOGENESIS; C-MET; ANDROGEN RECEPTOR; VEGF EXPRESSION; COMBINATION; BEVACIZUMAB; DOCETAXEL; SUNITINIB;
D O I：
10.1016/j.ucl.2012.07.010
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Antiangiogenic therapy has been successful for the treatment of solid tumors. Several strategies have been used to target angiogenesis in prostate cancer. These strategies include blocking proangiogenic factors via monoclonal antibodies or small molecule inhibitors targeting downstream signaling effector pathways, or using agents with immune-modulatory effects. This review examines the general concepts of tumor angiogenesis and the key clinical trials that have used these agents and other novel biologics in prostate cancer. Targeting angiogenesis is still a promising treatment strategy in prostate cancer with a rational trial design and combination approach.
引用
收藏
页码：547 / +
页数：15
相关论文
共 50 条
  • [41] Natural Products: A Promising Therapeutics for Targeting Tumor Angiogenesis
    Li, Ruyi
    Song, Xin
    Guo, Yanan
    Song, Peng
    Duan, Dongzhu
    Chen, Zhe-Sheng
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [42] Combination sonodynamic therapy with immunoadjuvant may be a promising new modality for cancer treatment
    Ma, Xiaopeng
    Pan, Huixuan
    Yi, Jilin
    MEDICAL HYPOTHESES, 2009, 72 (04) : 418 - 420
  • [43] Targeting the NF-κB Pathway in Prostate Cancer: A Promising Therapeutic Approach?
    Verzella, Daniela
    Fischietti, Mariafausta
    Capece, Daria
    Vecchiotti, Davide
    Del Vecchio, Filippo
    Cicciarelli, Germana
    Mastroiaco, Valentina
    Tessitore, Alessandra
    Alesse, Edoardo
    Zazzeroni, Francesca
    CURRENT DRUG TARGETS, 2016, 17 (03) : 311 - 320
  • [44] Cold atmospheric plasma, a novel promising anti-cancer treatment modality
    Yan, Dayun
    Sherman, Jonathan H.
    Keidar, Michael
    ONCOTARGET, 2017, 8 (09) : 15977 - 15995
  • [45] Patients' education level and treatment modality for prostate cancer in the Finnish Randomized Study of Screening for Prostate Cancer
    Kilpelainen, Tuomas P.
    Talala, Kirsi
    Taari, Kimmo
    Raitanen, Jani
    Kujala, Paula
    Pylvalainen, Juho
    Tammela, Teuvo L. J.
    Auvinen, Anssi
    EUROPEAN JOURNAL OF CANCER, 2020, 130 : 204 - 210
  • [46] Targeting the Mitochondrial Metabolic Network: A Promising Strategy in Cancer Treatment
    Frattaruolo, Luca
    Brindisi, Matteo
    Curcio, Rosita
    Marra, Federica
    Dolce, Vincenza
    Cappello, Anna Rita
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (17) : 1 - 21
  • [47] Antibodies Targeting KV Potassium Channels: A Promising Treatment for Cancer
    Hernandez-Resendiz, Ileana
    Hartung, Franziska
    Pardo, Luis A.
    BIOELECTRICITY, 2019, 1 (03): : 180 - 187
  • [48] Targeting Immune-Mediated Dormancy: A Promising Treatment of Cancer
    Wang, Hao-fan
    Wang, Sha-sha
    Huang, Mei-chang
    Liang, Xin-hua
    Tang, Ya-Jie
    Tang, Ya-ling
    FRONTIERS IN ONCOLOGY, 2019, 9
  • [49] Targeting neutrophil elastase is a promising direction for future cancer treatment
    Jia, Wangqiang
    Mao, Yudong
    Luo, Qianwen
    Wu, Jiang
    Guan, Quanlin
    DISCOVER ONCOLOGY, 2024, 15 (01)
  • [50] Integrating targeting and drug retention: A promising approach for cancer treatment
    Wang, Shenqiang
    Zhong, Zhiyuan
    JOURNAL OF CONTROLLED RELEASE, 2025, 378 : 247 - 249
12345