Papillomaviruses as targets for cancer gene therapy

被引:31
|
作者
Shillitoe, EJ [1 ]
机构
[1] SUNY, Upstate Med Univ, Dept Microbiol & Immunol, Syracuse, NY 13210 USA
关键词
review; papillomaviruses; cervical cancer; oral cancer; gene therapy;
D O I
10.1038/sj.cgt.7700926
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The human papillomaviruses (HPVs) are a diverse group of infectious agents, some of which are a causative agent of human cancers. Cervical cancer and oral cancer are closely associated with specific types of HPV, and the tumors grow only if there is continual expression of the viral E6 and E7 genes. Evidence from in vitro studies shows that when expression of these genes is inhibited by gene therapy approaches such as antisense RNA, ribozymes, or siRNA, the transformed phenotype of the cells is lost. Although it seems possible that clinical applications of this approach could help in the management of cervical and oral cancers there have been no clinical trials of gene therapy for HPV-associated cancers. Since the basic information is now available, a shift to translational research would be greatly welcomed.
引用
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页码:445 / 450
页数:6
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