Numerical design and experimental analysis of cell-based sensors

A novel numerical design of experimental analysis of cell-based sensors was introduced in the paper. In order to increase the signals to noise ratio and improve the performance of the chips, we analyzed cell-based sensors numerically and experimentally. Since the action potential which is about dozens of milliseconds changes quickly, we demonstrated an improved equivalent circuit model. Based on modeling of the interface between neuron and sensor, we predicted the experimental results. Furthermore, the experiment results indicate that the designed cell-based sensors can detect the extracellular AP, which meets the numerical consequence quite well.