Synthesis of chiral 3-acyl-4-alkylthiazolidine-2-thiones as enantioselective acylating agents

被引：0

作者：

Yadav, LDS ^{[1
]}

Dubey, S ^{[1
]}

机构：

[1] Univ Allahabad, Dept Chem, Allahabad 211002, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2002年 / 41卷 / 03期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

R-(-)-3-Benzoyl-4-ethylthiazolidine-2-thione 4a and S-(+)-3-benzoyl-4-isobutylthiazolidine-2-thione 4b have been easily prepared in 79-90% yield from R-(-)-2-amino-1-butanol la and S-(+)-leucinol 1b, respectively. Compounds 4a,b are useful for enantioselective acyl transfer to amine and amino acid racemates 5a-d in high yields (78-94%) and moderate to good optical purity (48-68% ee). One can monitor the acylation by disappearance of the yellow colour of the acylating agents 4a,b.

引用

页码：593 / 595

页数：3

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