Improved cell mediated immune responses after successful re-vaccination of non-responders to the hepatitis B virus surface antigen (HBsAg) vaccine using the combined hepatitis A and B vaccine

被引：25
|
作者：
Nystrom, Jessica [1 ]
Cardell, Kristina [2 ]
Bjornsdottir, Thora Bjorg [1 ]
Fryden, Aril [2 ]
Hultgren, Catharina [1 ]
Sallberg, Matti [1 ]
机构：
[1] Karolinska Univ Hosp Huddinge, Karolinska Inst, Div Clin Virol, S-14186 Huddinge, Sweden
[2] Linkoping Univ Hosp, Dept Infect Dis, S-58183 Linkoping, Sweden
来源：
VACCINE | 2008年 / 26卷 / 47期
关键词：
Hepatitis B virus; HBV; HBsAg; Vaccine; Non-responder;
D O I：
10.1016/j.vaccine.2008.08.054
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We Successfully re-vaccinated hepatitis B Virus (HBV) vaccine non-responders Using a double dose of the combined hepatitis A virus (HAV) and HBV vaccine. The hope was to improve priming of hepatitis B surface antigen (HBsAg)-specific cell mediated immune response (CMI) by an increased antigen dose and a theoretical adjuvant-effect from the local presence of a HAV-specific CMI. A few non-responders had a detectable HBsAg-specific CMI before re-vaccination. An in vitro detectable HBsAg-specific CMI was primed equally effective in non-responders (58%) as in first time vaccine recipients (68%). After the third dose a weak, albeit significant, association was observed between the magnitude of HBsAg-specific proliferation and anti-HBs levels. This regimen improves the priming of HBsAg-specific CMIs and antibodies. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5967 / 5972
页数：6
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