Improved cell mediated immune responses after successful re-vaccination of non-responders to the hepatitis B virus surface antigen (HBsAg) vaccine using the combined hepatitis A and B vaccine

被引：25

作者：

Nystrom, Jessica ^{[1
]}

Cardell, Kristina ^{[2
]}

Bjornsdottir, Thora Bjorg ^{[1
]}

Fryden, Aril ^{[2
]}

Hultgren, Catharina ^{[1
]}

Sallberg, Matti ^{[1
]}

机构：

[1] Karolinska Univ Hosp Huddinge, Karolinska Inst, Div Clin Virol, S-14186 Huddinge, Sweden

[2] Linkoping Univ Hosp, Dept Infect Dis, S-58183 Linkoping, Sweden

来源：

VACCINE | 2008年 / 26卷 / 47期

关键词：

Hepatitis B virus; HBV; HBsAg; Vaccine; Non-responder;

D O I：

10.1016/j.vaccine.2008.08.054

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We Successfully re-vaccinated hepatitis B Virus (HBV) vaccine non-responders Using a double dose of the combined hepatitis A virus (HAV) and HBV vaccine. The hope was to improve priming of hepatitis B surface antigen (HBsAg)-specific cell mediated immune response (CMI) by an increased antigen dose and a theoretical adjuvant-effect from the local presence of a HAV-specific CMI. A few non-responders had a detectable HBsAg-specific CMI before re-vaccination. An in vitro detectable HBsAg-specific CMI was primed equally effective in non-responders (58%) as in first time vaccine recipients (68%). After the third dose a weak, albeit significant, association was observed between the magnitude of HBsAg-specific proliferation and anti-HBs levels. This regimen improves the priming of HBsAg-specific CMIs and antibodies. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5967 / 5972

页数：6

共 50 条

[1] Recent advances in vaccination of non-responders to standard dose hepatitis B virus vaccine
Saqib Walayat
Zohair Ahmed
Daniel Martin
Srinivas Puli
Michael Cashman
Sonu Dhillon
World Journal of Hepatology, 2015, 7 (24) : 2503 - 2509
[2] Recent advances in vaccination of non-responders to standard dose hepatitis B virus vaccine
Walayat, Saqib
Ahmed, Zohair
Martin, Daniel
Puli, Srinivas
Cashman, Michael
Dhillon, Sonu
WORLD JOURNAL OF HEPATOLOGY, 2015, 7 (24) : 2503 - 2509
[3] Predictive effect of five hepatitis B virus markers on re-vaccination time of hepatitis B vaccine
Jia, Qiuhua
Yu, Fei
Zhou, Qi
Chen, Xiaoyan
Gu, Zhaoqi
Ma, Chunling
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2020, 20 (02) : 1709 - 1715
[4] Hepatitis B vaccine induces cellular immune responses in most humoral non-responders
Bauer, T.
Broodhaers, S.
Van Damme, P.
Jilg, W.
JOURNAL OF CLINICAL VIROLOGY, 2006, 36 : S165 - S165
[5] Immune response to hepatitis B vaccine with high antigen content in non-responders after standard primary vaccination in Chinese adults
Pan, Hong-Xing
Zeng, Ying
Song, Xue-Fang
Zhang, Yi-Ju
Xu, Ke
Liang, Zheng-Lun
Zhu, Feng-Cai
VACCINE, 2014, 32 (29) : 3706 - 3712
[6] Characterization of hepatitis B virus surface antigen-specific CD4+T cells in hepatitis B vaccine non-responders
Suzuki, T
Yamauchi, K
Kuwata, T
Hayashi, N
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2001, 16 (08) : 898 - 903
[7] New vaccination strategies for low- and non-responders to hepatitis B vaccine
Rendi-Wagner, P
Wiedermann, G
Stemberger, H
Kollaritsch, H
WIENER KLINISCHE WOCHENSCHRIFT, 2002, 114 (5-6) : 175 - 180
[8] Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination
Rottinghaus, ST
Poland, GA
Jacobson, RM
Barr, LJ
Roy, MJ
VACCINE, 2003, 21 (31) : 4604 - 4608
[9] Investigation of memory B cell responses to hepatitis B surface antigen in health care workers considered as non-responders to vaccination
Valats, J. C.
Tuaillon, E.
Funakoshi, N.
Hoa, D.
Brabet, M. C.
Bollore, K.
Ducos, J.
Vendrell, J. P.
Blanc, P.
VACCINE, 2010, 28 (39) : 6411 - 6416
[10] HIGH PREVALENCE OF OCCULT HEPATITIS B VIRUS INFECTION IN NON-RESPONDERS TO HEPATITIS B VACCINE AND HBIG FROM CHILDREN BORN TO HBSAG POSITIVE MOTHERS
Jazayeri, S. M.
Yahyapoor, Y.
Mahmoodi, M.
Alavian, S. M.
JOURNAL OF HEPATOLOGY, 2011, 54 : S440 - S440

← 1 2 3 4 5 →