Synthesis of New Thienopyridine Derivatives by [3+2]- and [2+2]-Cycloaddition Reactions

被引：7
|
作者：
Milen, Matyas [1 ,2 ]
Abranyi-Balogh, Peter [1 ]
Dancso, Andras [2 ]
Keglevich, Gyoergy [1 ]
机构：
[1] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary
[2] EGIS Pharmaceut PLC, Div Chem Res, H-1475 Budapest, Hungary
来源：
SYNTHESIS-STUTTGART | 2012年 / 44卷 / 22期
关键词：
heterocycles; cycloadditions; nitrile oxides; nitrile imines; Staudinger reactions; NITRILE OXIDES; CYCLOADDITION REACTIONS; CLOPIDOGREL; NITRILIMINES; 3,4-DIHYDRO-BETA-CARBOLINES; 1,3-DIPOLES; TICLOPIDINE; STAUDINGER; PRECURSORS; REACTIVITY;
D O I：
10.1055/s-0032-1316794
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of 6,7-dihydrothieno[3,2-c]pyridine derivatives with 1,3-dipoles, such as a nitrile oxides or nitrile imines, gave novel fused heterocycles. The Staudinger reaction of the starting material was also studied. This reaction was stereoselective and exclusively gave racemic cis-cycloadducts in which the thienopyridine core was fused with a beta-lactam ring.
引用
收藏
页码：3447 / 3452
页数：6
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