Synthesis and hypolipidemic activity of diesters of arylnaphthalene lignan and their heteroaromatic analogs

被引：0
|
作者：
Kuroda, T [1 ]
Kondo, K [1 ]
Iwasaki, T [1 ]
Ohtani, A [1 ]
Takashima, K [1 ]
机构：
[1] TANABE SEIYAKU CO LTD, RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1997年 / 45卷 / 04期
关键词：
lignan; hypocholesterolemic activity; high-density lipoprotein;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of diesters of arylnaphthalene lignan and their heteroaromatic analogs were synthesized and evaluated for hypolipidemic activity. Tbe diesters with modifications at C-3 showed excellent hypocholesterolemic and high-density Lipoprotein (HDL) cholesterol-elevating activities. Structure-activity analysis indicated that the 2-pyridylmethyl ester 51 has the optimum activity.
引用
收藏
页码：678 / 684
页数：7
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