ANTAGONISTS OF AMPA/KA AND NMDA (GLYCINE SITE) GLUTAMATE RECEPTORS

被引：0
|
作者：
Kadieva, M. G. [1 ]
Oganesyan, E. T. [2 ]
Zefirova, O. H. [3 ]
机构：
[1] Chem Divers Res Inst, Chimki, Moscow Region, Russia
[2] Pyatigorsk State Pharmaceut Acad, Pyatigorsk, Russia
[3] Moscow MV Lomonosov State Univ, Moscow 117234, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2008年 / 42卷 / 02期
关键词：
D O I：
10.1007/s11094-008-0063-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The present review systematizes studies of recent years on the structure-activity relationship of antagonists of the glycine site of NMDA-type glutamate receptors and antagonists of AMPA/kainate-type glutamate receptors. Extreme activation of ionotropic glutamate receptors is known to promote the development of a number of socially important diseases, such as Alzheimer's disease and Parkinson's disease. Construction of inhibitors of these receptors is therefore one of the major directions in contemporary medicinal chemistry. This review may be useful for specialists engaged in the development of new pharmacologically active substances.
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页码：72 / 80
页数：9
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