Comparative analysis of differentiation and behavior of human neural and mesenchymal stem cells in vitro and in vivo

被引：6

作者：

Aleksandrova, M. A. ^{[1
]}

Sukhikh, G. T.

Chailakhyan, R. K.

Podgornyi, O. V.

Marei, M. V.

Poltavtseva, R. A.

Gerasimov, Yu. V.

机构：

[1] Russian Acad Sci, Inst Dev Biol, Moscow, Russia

[2] Russian Acad Med Sci, Ctr Obster Gynecol & Perinatol, Moscow, Russia

[3] NF Gamalei Inst Epidemiol & Microbiol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

neural stem cells; mesenchymal stem cells; differentiation; filament growth; immunohistochemistry;

D O I：

10.1007/s10517-006-0116-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Comparative analysis of differentiation of human neural and mesenchymal stem cells in tissue culture and after transplantation into the brain was carried out using the same antibody set. Neural stem cells differentiated into all types of neural cells, are retained after transplantation, migrate, and form reciprocal relationships with the recipient brain. Mesenchymal stem cells were incapable of neural development under conditions of common culturing or after transplantation and retained the fibroblast-like status. Recipient filaments grew into mesenchymal stem cell transplants containing no neural cells due to local changes in the extracellular matrix at the site of transplantation.

引用

页码：152 / 160

页数：9

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