HLA-DMA and HLA-DMB genotyping in patients with systemic lupus erythematosus

被引：0
|
作者：
Yen, JH [1 ]
Chen, CJ [1 ]
Tsai, WC [1 ]
Tsai, JJ [1 ]
Ou, TT [1 ]
Liu, HW [1 ]
机构：
[1] Kaohsiung Med Coll, Dept Internal Med, Div Rheumatol, Kaohsiung 807, Taiwan
来源：
JOURNAL OF RHEUMATOLOGY | 1999年 / 26卷 / 09期
关键词：
HLA-DMA; HLA-DMB; MHC; systemic lupus erythematosus;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective. To investigate the relation of HLA-DMA and DMB alleles to the development of systemic lupus erythematosus (SLE). Methods. We studied HLA-DMA and Dh IB alleles in 108 patients with SLE and 138 healthy controls using the amplification created restriction site method. Results. The phenotypic frequency of HLA-DMA*0104 was significantly higher in patients with SLE than in healthy controls. The HLA-DMA and DMB alleles were not related to clinical manifestations and various laboratory tests in patients with SLE. Conclusion, HLA-DMA*0104 may be associated with the susceptibility of SLE.
引用
收藏
页码：1930 / 1933
页数：4
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