Synthesis of new indole-2-carboxamide and 3-acetamide derivatives and evaluation their antioxidant properties

被引：18
|
作者：
Olgen, Sureyya [1 ]
Bakar, Filiz [2 ]
Aydin, Semra [1 ]
Nebioglu, Dogu [1 ]
Nebioglu, Serpil [2 ]
机构：
[1] Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey
[2] Ankara Univ, Fac Pharm, Dept Biochem, TR-06100 Ankara, Turkey
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2013年 / 28卷 / 01期
关键词：
Indole-2-carboxamide and 3-acetamide; hemeoxygenase; DPPH; antioxidant; HEME OXYGENASE; N-H; INDOLE-DERIVATIVES; SUBSTITUTED INDOLE; INHIBITORS; SERIES; MONOXIDE; PROTEIN; STRESS; SYSTEM;
D O I：
10.3109/14756366.2011.631183
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In recent years, antioxidant compounds play an important role as a health-protecting factor. Antioxidants protect cells against the damaging effects of reactive oxygen species (ROS). An imbalance between antioxidants and ROS results in oxidative stress, which leads to cellular damage and it is linked to many vital diseases. It was shown that heme oxygenase (HO) provides efficient cytoprotection against oxidative stress. In this study, a series of indole-2-carboxamide and 3-acetamide derivatives was tested for in vitro effects on HO activity and 2,2-diphenyl-1-picrylhydrazyl (DPPH) inhibition. Among the synthesized compounds, N-[3-(dimethylamino)propyl]-1H-indole-2-carboxamide 3 was found as the most activator of HO and N-(2-(dimethylamino)ethyl)-2-(1H-indol-3-yl)acetamide 8 was found the most potent inhibitor for DPPH at 10(-4) M concentration.
引用
收藏
页码：58 / 64
页数：7
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