Enhanced pulmonary accumulation of liposomal amphotericin B (AmBisome) in acute liver transplant failure

被引：16

作者：

Heinemann, V ^{[1
]}

Bosse, D ^{[1
]}

Jehn, U ^{[1
]}

Debus, A ^{[1
]}

Wachholz, K ^{[1
]}

Forst, H ^{[1
]}

Wilmanns, W ^{[1
]}

机构：

[1] ZENT KLINIKUM,INST ANAESTHESIOL,AUGSBURG,GERMANY

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1997年 / 40卷 / 02期

关键词：

D O I：

10.1093/jac/40.2.295

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Plasma and tissue concentrations of amphotericin B were determined in a patient treated with liposomal amphotericin B during liver transplant failure. A cumulative rise in amphotericin B plasma concentrations was observed accompanied by an enhanced pulmonary deposition of the drug, Failure of the liver as a major component of the reticuloendothelial system may cause elevated plasma concentrations of liposomal amphotericin B and may consequently enhance deposition of liposomes in the lungs as a substitutive clearing organ.

引用

页码：295 / 297

页数：3

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