Possible artemisinin-based combination therapy-resistant malaria in Nigeria: a report of three cases

被引：22
|
作者：
Ajayi, Nnennaya Anthony [1 ]
Ukwaja, Kingsley Nnanna [1 ]
机构：
[1] Fed Teaching Hosp Abakaliki, Dept Internal Med, Abakaliki 23433, Ebonyi State, Nigeria
来源：
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2013年 / 46卷 / 04期
关键词：
Malaria; Artemisinin-based combination therapy; Artemether-lumefantrine; Early treatment failure; Resistance; Nigeria; PLASMODIUM-FALCIPARUM MALARIA; ARTEMETHER-LUMEFANTRINE; TREATMENT FAILURE; TRAVELER;
D O I：
10.1590/0037-8682-0098-2013
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Artemisinin-based combination therapy-resistant malaria is rare in Sub-Saharan Africa. The World Health Organization identifies monitoring and surveillance using day-3 parasitaemia post-treatment as the standard test for identifying suspected artemisinin resistance. We report three cases of early treatment failure due to possible artemisinin-based combination therapy-resistant Plasmodium falciparum malaria. All cases showed adequate clinical and parasitological responses to quinine. This study reveals a need to re-evaluate the quality and efficacy of artemisinin-based combination therapy agents in Nigeria and Sub-Saharan Africa.
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页码：525 / 527
页数：3
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