Prolonged Survival of Patients with Breast Cancer-related Leptomeningeal Metastases

被引：0

作者：

Le Rhun, Emilie ^{[1
,2
]}

Taillibert, Sophie ^{[3
,4
]}

Zairi, Fahed ^{[2
]}

Pannier, Diane ^{[1
]}

Boulanger, Thomas ^{[5
]}

Andre, Charles ^{[6
]}

Cazin, Jean Louis ^{[7
]}

Dubois, Francois ^{[2
]}

Bonneterre, Jacques ^{[8
]}

Chamberlain, Marc C. ^{[9
]}

机构：

[1] Ctr Oscar Lambret, Dept Med Oncol, Breast Unit, F-59020 Lille, France

[2] Univ Hosp, Dept Neurosurg, Lille, France

[3] Grp Hosp Pitie Salpetriere, Dept Radiat Oncol, F-75634 Paris, France

[4] Grp Hosp Pitie Salpetriere, Dept Neurooncol, F-75634 Paris, France

[5] Ctr Oscar Lambret, Dept Radiol, F-59020 Lille, France

[6] Ctr Oscar Lambret, Dept Pathol, F-59020 Lille, France

[7] Ctr Oscar Lambret, Dept Clin Pharm, F-59020 Lille, France

[8] Univ Lille Nord France, Lille, France

[9] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

来源：

ANTICANCER RESEARCH | 2013年 / 33卷 / 05期

关键词：

Leptomeningeal metastases; neoplastic meningitis; intra-CSF chemotherapy; liposomal cytarabine; breast cancer; multimodality treatment; CARCINOMATOUS MENINGITIS SECONDARY; PROGNOSTIC-FACTORS; MENINGEAL CARCINOMATOSIS; NEOPLASTIC MENINGITIS; INTRATHECAL METHOTREXATE; CLINICAL-FEATURES; CHEMOTHERAPY; TUMOR;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Prolonged overall survival (OS) has been reported for selected patients with leptomeningeal metastases (LM). The management and treatment of such patients is poorly-described. We report our experience on breast cancer (BC)-associated LM and patients with prolonged survival. Patients and Methods: Eleven patients with BC and LM had an OS >12 months in which treatment is described. Results: Combined intra-cerebro spinal fluid (CSF) and systemic treatment were administered until disease progression or toxicity in all but two patients. Involved-field radiotherapy was administered to two patients. Median OS in this selected cohort following LM diagnosis, was 21.0 (range=13-33.3) months. Conclusion: Prolonged OS but also prolonged responses can be observed in BC with LM. An individualized and multi-disciplinary approach is advised for the management of these patients.

引用

页码：2057 / 2063

页数：7

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