Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine

被引：11

作者：

Winokur, Patricia L. ^{[1
,2
]}

Patel, Shital M. ^{[3
,4
]}

Brady, Rebecca ^{[5
]}

Chen, Wilbur H. ^{[6
]}

El-Kamary, Samer S. ^{[6
]}

Edwards, Kathryn ^{[8
]}

Creech, C. Buddy ^{[8
]}

Frey, Sharon

Keitel, Wendy A. ^{[4
]}

Belshe, Robert ^{[9
]}

Walter, Emmanuel ^{[10
]}

Bellamy, Abbie ^{[7
]}

Hill, Heather ^{[7
]}

机构：

[1] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA

[2] Iowa City VA Healthcare Syst, Iowa City, IA USA

[3] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[5] Cincinnati Childrens Hosp, Gamble Program Clin Studies, Cincinnati, OH USA

[6] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA

[7] EMMES Corp, Rockville, MD USA

[8] Vanderbilt Univ, Dept Pediat, Nashville, TN 37235 USA

[9] St Louis Univ, Dept Internal Med, St Louis, MO 63103 USA

[10] Duke Univ, Sch Med, Dept Pediat, Durham, NC USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2015年 / 212卷 / 04期

基金：

美国国家卫生研究院;

关键词：

H5N1; influenza; vaccine; prime-boost; MEMORY B-CELLS; PANDEMIC INFLUENZA; ANTIGENIC VARIANT; HUMANS;

D O I：

10.1093/infdis/jiv087

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Influenza A(H5N1) vaccination strategies that improve the speed of the immunological response and cross-clade protection are desired. We compared the immunogenicity of a single 15-mu g or 90-mu g dose of A/H5N1/Indonesia/05/05 (clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (clade 1) vaccine. High-dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low-dose priming with a mismatched pandemic influenza A(H5N1) vaccine would improve the rapidity, magnitude, and cross-reactivity of the immunological response following a single high-dose, unadjuvanted, pandemic vaccine.

引用

页码：525 / 530

页数：6

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