Structural Insights into the Evolutionarily Conserved BAF Chromatin Remodeling Complex

被引：3
|
作者：
Marcum, Ryan D. [1 ]
Reyes, Alexis A. [1 ,2 ]
He, Yuan [1 ,2 ,3 ]
机构：
[1] Northwestern Univ, Dept Mol Biosci, 2205 Tech Dr, Evanston, IL 60208 USA
[2] Northwestern Univ, Interdisciplinary Biol Sci Program, 2205 Tech Dr, Evanston, IL 60208 USA
[3] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, 676 N St Clair, Chicago, IL 60611 USA
来源：
BIOLOGY-BASEL | 2020年 / 9卷 / 07期
关键词：
chromatin remodeling; cancer; SWI; SNF complex; BAF complex; cryo-EM; SMALL-CELL CARCINOMA; MAMMALIAN SWI/SNF COMPLEXES; TUMOR-SUPPRESSOR; EPITHELIOID SARCOMA; SMARCA4; MUTATIONS; SOMATIC MUTATIONS; ARID1A MUTATIONS; SOFT-TISSUE; BRG1; MECHANISMS;
D O I：
10.3390/biology9070146
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The switch/sucrose nonfermentable (SWI/SNF) family of proteins acts to regulate chromatin accessibility and plays an essential role in multiple cellular processes. A high frequency of mutations has been found in SWI/SNF family subunits by exome sequencing in human cancer, and multiple studies support its role in tumor suppression. Recent structural studies of yeast SWI/SNF and its human homolog, BAF (BRG1/BRM associated factor), have provided a model for their complex assembly and their interaction with nucleosomal substrates, revealing the molecular function of individual subunits as well as the potential impact of cancer-associated mutations on the remodeling function. Here we review the structural conservation between yeast SWI/SNF and BAF and examine the role of highly mutated subunits within the BAF complex.
引用
收藏
页码：1 / 9
页数：9
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