Simultaneous determination of canrenone, digoxin and tolvaptan by UHPLC-MS/MS: application in heart failure patients

被引：8
|
作者：
Guo, Peng [1 ]
Liang, Qiucheng [2 ]
Zheng, Juntao [1 ]
Chen, Jinmin [2 ]
Guan, Yanping [3 ]
Ding, Liang [4 ]
Jiang, Fulin [1 ]
Chen, Xuewen [2 ]
Huang, Min [1 ]
Chen, Ailan [2 ]
Zhong, Guoping [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Clin Pharmacol, Guangzhou 510006, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Affiliated Hosp 1, Cardiovasc Dept, Guangzhou 510120, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Pharm, Guangzhou 510120, Guangdong, Peoples R China
[4] Peoples Hosp Shenzhen Baoan Dist, Clin Trial & Res Ctr, Shenzhen 518101, Guangdong, Peoples R China
来源：
BIOANALYSIS | 2020年 / 12卷 / 09期
基金：
中国国家自然科学基金;
关键词：
canrenone; digoxin; drug-drug interactions; heart failure; tolvaptan; UHPLC-MS; MS; HUMAN PLASMA; DRUG INTERACTIONS; SPIRONOLACTONE; QUANTIFICATION; NANOPARTICLES; METABOLITES; MORBIDITY; MORTALITY; THERAPY;
D O I：
10.4155/bio-2020-0037
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Aim: Heart failure patients are frequently given comedication of digoxin and diuretics like spironolactone and tolvaptan. A UHPLC-MS/MS assay for determining canrenone (main active metabolite of spironolactone), digoxin and tolvaptan simultaneously should be developed so as to support related drug-drug interaction studies. Results: A UHPLC-MS/MS method for simultaneous determination of these three drugs in human plasma was established and fully verified as per CFDA guidelines. Chromatographic separation was achieved using a 4-min isocratic elution. Mass analyses were performed under positive electrospray ionization mode. The calibration curves were established over 1.0-400.0 ng/ml for canrenone and tolvaptan while over 0.1-40.0 ng/ml for digoxin. Conclusion: The developed method was feasible in detecting concentration and related drug-drug interaction studies.
引用
收藏
页码：569 / 582
页数：14
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