Unraveling the role of genetics in the pathogenesis of diabetic retinopathy

被引：27

作者：

Sharma, Ashok ^{[1
,2
]}

Valle, Maria L. ^{[1
]}

Beveridge, Connor ^{[1
]}

Liu, Yutao ^{[1
,3
]}

Sharma, Shruti ^{[1
,4
]}

机构：

[1] Augusta Univ, Ctr Biotechnol & Genom Med, Med Coll Georgia, Augusta, GA 30912 USA

[2] Augusta Univ, Med Coll Georgia, Dept Populat Hlth Sci, Augusta, GA 30912 USA

[3] Augusta Univ, Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA 30912 USA

[4] Augusta Univ, Med Coll Georgia, Dept Ophthalmol, Augusta, GA 30912 USA

来源：

EYE | 2019年 / 33卷 / 04期

关键词：

GENOME-WIDE ASSOCIATION; CHINESE PATIENTS; PROLIFERATIVE RETINOPATHY; ENDOTHELIAL DYSFUNCTION; ADHESION MOLECULE-1; GROWTH-FACTOR; INSULIN; POLYMORPHISMS; METAANALYSIS; VARIANT;

D O I：

10.1038/s41433-019-0337-y

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented in this review will be helpful in unraveling the role of genetics in the pathogenesis of DR.

引用

页码：534 / 541

页数：8

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