Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom Ganoderma australe

被引：3

作者：

Zhou, Lin ^{[1
]}

Chen, He-Ping ^{[1
]}

Li, Xinyang ^{[1
,2
]}

Liu, Ji-Kai ^{[1
]}

机构：

[1] South Cent Minzu Univ, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China

[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

PHARMACEUTICALS | 2022年 / 15卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Ganoderma australe (Fr; ) Pat; Polyporaceae; triterpenes; anti-BACE1; activity; FRUITING BODIES; POLYCYCLIC MEROTERPENOIDS; CYTOTOXIC TRITERPENOIDS; LANOSTANE TRITERPENOIDS; SECONDARY METABOLITES; PAIR; INHIBITORS; POTENT;

D O I：

10.3390/ph15121520

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two triterpenes, ganoaustralins A (1) and B (2), featuring unprecedented 6/6/6/5/6 scaffolds were isolated from the fruiting bodies of the mushroom Ganoderma australe. The structures were determined by extensive NMR and HRESIMS spectroscopic analysis. The absolute configuration of the C-25 in ganoaustralin A was assigned by the phenylglycine methyl ester (PGME) method. The relative and absolute configurations of the polycyclic backbones were determined by NMR and ECD calculations, respectively. The plausible biosynthetic pathways of ganoaustralins A and B were proposed. Ganoaustralin B showed weak inhibition against beta-secretase 1.

引用

页数：10

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